Increasing Lifespans/Healthspans

Increasing Lifespans/Healthspans

News on longer, healthier lives
Owner: Shekerev
This is a public group.


Right now there is an explosion of positive research results on life extension, cancer treatments, cardiovascular disease, type 2 diabetes, etc. Simultaneously, there are several positive research results on improving health spans.

This group will report on the most important ones and provide a forum for discussion.


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24 Member

  • Michael Ferguson
  • Leif
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  • Gwyneth Wesley Rolph
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  • Shekerev
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The Wall

16 Wall Posts

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  • Shekerev
    by Shekerev 1 year ago
    There is an interesting medical device by a Silicon Valley company NeuroPace.

    It a small, implantable neurostimulator connected to leads (tiny wires) that are placed in up to two seizure onset areas. It comes with a simple remote monitor that you use at home to wirelessly collect information from the neurostimulator and then transfer it to the Patient Data Management System (PDMS). Your doctor supposedly can also log into the PDMS at any time to review accurate, ongoing information about your seizure activity and treatment progress. This helps your doctor learn more about your seizures and improve your care.
    2. In clinical trials, adults treated with the RNS® System experienced significant, long-term seizure reduction and compelling quality of life improvements. Some individuals also showed benefit in memory and language. Seizure reduction over time for patients treated with the RNS System. By year three, patients reported 60% seizure reduction. This continued to improve, with 66% seizure reduction by year six.
    There is still ongoing research in various academic centres, but it does sound promising.
  • Shekerev
    by Shekerev 2 years ago
    One of the few interesting wearables that I have seen.
    I will test it personally as soon as possible :)
  • Shekerev
    by Shekerev 2 years ago
    " To the best of our knowledge, it seems that UA through enhancing of anti-aging biomarkers (SIRT1 and SIRT6) and PGC-1β in hypothalamus regulates aging-process and attenuates mitochondrial-related diseases. In regard to the key role of α-Klotho in aging, our data indicate that UA may be on the horizon to forestall diseases of aging"
  • Shekerev
    by Shekerev 2 years ago
    I totally did not see this coming. Definitely worth a look!
  • Shekerev
    by Shekerev 2 years ago
    Top 5 Healthcare and Longevity posts for March 2016

    Researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the US has now given the go-ahead for a trial to see if the same effects can be replicated in humans.It is actually the world’s most widely used diabetes drug, which on top of that only costs just 10p [15 cents] a day.
    Metformin enhances the activity of an enzyme found within our cells called adenosine monophosphate-activated protein kinase—or AMPK for short. AMPK activation helps mimic the beneficial effects of calorie restriction, the best documented method of slowing and reversing biomarkers of human aging.
    A new minimally invasive surgical method has been developed that allows regeneration of a functional lens with refractive and accommodative abilities, and with greater visual axis transparency. This new cataract treatment uses endogenous stem cells to replenish the human ocular lens, and provides a fresh paradigm for organ and tissue regeneration.
    A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes – a specific virus and two specific types of bacteria – are major causes of Alzheimer’s Disease. According to the authors there is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component, and that this can be woken up by iron dysregulation. Removing this iron will slow down or prevent cognitive degeneration
  • Shekerev
    by Shekerev 2 years ago
    Lifestyle choices, particularly diet, exercise and smoking habits, play an undisputed role in determining not only how long one will live, but also how well one ages.
    Research suggests that exceptional longevity (EL)in one to three decades beyond the average U.S. life span of approximately 80 years—runs strongly in families.
    The researchers found that, based on subjects' genetic profiles, the centenarians could be divided into 19 subgroups, some of which were associated with delayed onset of age-related diseases such as dementia, hypertension and cardiovascular disease. These signatures represent different genetic paths to age 100 and beyond.
  • Shekerev
    by Shekerev 2 years ago
    “We found that we could mimic cortical folding using a very simple physical principle and get results qualitatively similar to what we see in real fetal brains,” said L. Mahadevan, the Lola England de Valpine Professor of Applied Mathematics, Organismic and Evolutionary Biology, and Physics.

    To mimic cortical expansion, the gel brain was immersed in a solvent that is absorbed by the outer layer, causing it to swell relative to the deeper regions. Within minutes of being immersed in liquid solvent, the resulting compression led to the formation of folds similar in size and shape to real brains.
  • Shekerev
    by Shekerev 2 years ago
    By analysis of 77 plasma proteins in 976 individuals, that the abundance of circulating proteins accurately predicts chronological age, as well as anthropometrical measurements such as weight, height and hip circumference. The plasma protein profile can also be used to identify lifestyle factors that accelerate and decelerate ageing.
  • Shekerev
    by Shekerev 2 years ago
    After taking the T cells, the researchers then genetically engineer them with synthetic molecules called chimeric antigen receptors (CAR). The CARs enable the T cells to attack the body’s cancer cells. The army of cancer-fighting cells is grown in a lab and then given back to the patient. The therapy does not need to be repeatedly administered because T cells can continue to multiply once delivered back into the patient.

    The researchers noticed dramatic remissions in the treatment of patients with two types of cancers: lymphomas and some types of leukemias. However, while the treatment shows promising results, “much like chemotherapy and radiotherapy, it’s not going to be a save-all,” said Immunotherapy researcher and oncologist Stanley Riddell. Some patients may require alternative treatments.
  • Shekerev
    by Shekerev 2 years ago
    The study shows that atorvastatin—the most commonly used cholesterol-lowering medication—effectively reduces immune activation, thereby diminishing the systemic inflammation that leads to premature or accelerated aging.